Publications

  1. Assessing cost-effectiveness of early intervention in Alzheimer's disease: An open-source modeling framework. Green, C, Handels, R, Gustavsson, A, Wimo, A, Winblad, B, Sköldunger, A, Jönsson, L. PubMed PMID:31402324
  2. Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype. Vermunt, L, Sikkes, SAM, van den Hout, A, Handels, R, Bos, I, van der Flier, WM, Kern, S, Ousset, PJ, Maruff, P, Skoog, I, Verhey, FRJ, Freund-Levi, Y, Tsolaki, M, Wallin, ÅK, Olde Rikkert, M, Soininen, H, Spiru, L, Zetterberg, H, Blennow, K, Scheltens, P, Muniz-Terrera, G, Visser, PJ, Alzheimer Disease Neuroimaging Initiative, AIBL Research Group, ICTUS/DSA study groups. PubMed PMID:31164314
  3. Do caregiver profiles predict the use of dementia care services? Findings from the Actifcare study. Kerpershoek, L, Woods, B, Wolfs, C, Verhey, F, Jelley, H, Bieber, A, Stephan, A, Michelet, M, Selbaek, G, Handels, R, Wimo, A, Hopper, L, Irving, K, Marques, MJ, Gonçalves-Pereira, M, Portolani, E, Zanetti, O, de Vugt, M, and the Actifcare Consortium. PubMed PMID:30518244
  4. Impact of Untimely Access to Formal Care on Costs and Quality of Life in Community Dwelling People with Dementia. Janssen, N, Handels, RL, Sköldunger, A, Woods, B, Jelley, H, Edwards, RT, Orrell, M, Selbæk, G, Røsvik, J, Gonçalves-Pereira, M, Marques, MJ, Zanetti, O, Portolani, E, Irving, K, Hopper, L, Meyer, G, Bieber, A, Stephan, A, Kerpershoek, L, Wolfs, CAG, de Vugt, ME, Verhey, FRJ, Wimo, A, Consortium Actifcare. PubMed PMID:30400096
  5. Quality of Life, Care Resource Use, and Costs of Dementia in 8 European Countries in a Cross-Sectional Cohort of the Actifcare Study. Handels, RLH, Sköldunger, A, Bieber, A, Edwards, RT, Gonçalves-Pereira, M, Hopper, L, Irving, K, Jelley, H, Kerpershoek, L, Marques, MJ, Meyer, G, Michelet, M, Portolani, E, Røsvik, J, Selbaek, G, Stephan, A, de Vugt, M, Wolfs, C, Woods, B, Zanetti, O, Verhey, F, Wimo, A, and Actifcare consortium. PubMed PMID:30372674
  6. Cognitive behavioural therapy for anxiety disorders in Parkinson's disease: Design of a randomised controlled trial to assess clinical effectiveness and changes in cerebral connectivity. Mulders, AEP, Moonen, AJH, Dujardin, K, Kuijf, ML, Duits, A, Flinois, B, Handels, RLH, Lopes, R, Leentjens, AFG. PubMed PMID:30097133
  7. Systematic literature review of methodologies and data sources of existing economic models across the full spectrum of Alzheimer's disease and dementia from apparently healthy through disease progression to end of life care: a systematic review protocol. Karagiannidou, M, Wittenberg, R, Landeiro, FIT, Park, AL, Fry, A, Knapp, M, Gray, AM, Tockhorn-Heidenreich, A, Castro Sanchez, AY, Ghinai, I, Handels, R, Lecomte, P, Wolstenholme, J, ROADMAP Group. PubMed PMID:29884696
  8. Measuring quality of life of people with predementia and dementia and their caregivers: a systematic review protocol. Landeiro, F, Walsh, K, Ghinai, I, Mughal, S, Nye, E, Wace, H, Roberts, N, Lecomte, P, Wittenberg, R, Wolstenholme, J, Handels, R, Roncancio-Diaz, E, Potashman, MH, Tockhorn-Heidenreich, A, Gray, AM, ROADMAP Group. PubMed PMID:29602838
  9. Resource utilisation and costs in predementia and dementia: a systematic review protocol. Landeiro, F, Wace, H, Ghinai, I, Nye, E, Mughal, S, Walsh, K, Roberts, N, Lecomte, P, Wittenberg, R, Wolstenholme, J, Handels, R, Roncancio-Diaz, E, Potashman, MH, Tockhorn-Heidenreich, A, Gray, AM, ROADMAP Group. PubMed PMID:29362261
  10. Cost-Utility of Using Alzheimer's Disease Biomarkers in Cerebrospinal Fluid to Predict Progression from Mild Cognitive Impairment to Dementia. Handels, RLH, Wimo, A, Dodel, R, Kramberger, MG, Visser, PJ, Molinuevo, JL, Verhey, FRJ, Winblad, B. PubMed PMID:29081416
  11. Cerebrospinal fluid and blood biomarkers for neurodegenerative dementias: An update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry. Lewczuk, P, Riederer, P, O'Bryant, SE, Verbeek, MM, Dubois, B, Visser, PJ, Jellinger, KA, Engelborghs, S, Ramirez, A, Parnetti, L, Jack, CR Jr, Teunissen, CE, Hampel, H, Lleó, A, Jessen, F, Glodzik, L, de Leon, MJ, Fagan, AM, Molinuevo, JL, Jansen, WJ, Winblad, B, Shaw, LM, Andreasson, U, Otto, M, Mollenhauer, B, Wiltfang, J, Turner, MR, Zerr, I, Handels, R, Thompson, AG, Johansson, G, Ermann, N, Trojanowski, JQ, Karaca, I, Wagner, H, Oeckl, P, van Waalwijk van Doorn, L, Bjerke, M, Kapogiannis, D, Kuiperij, HB, Farotti, L, Li, Y, Gordon, BA, Epelbaum, S, Vos, SJB, Klijn, CJM, Van Nostrand, WE, Minguillon, C, Schmitz, M, Gallo, C, Lopez Mato, A, Thibaut, F, Lista, S, Alcolea, D, Zetterberg, H, Blennow, K, Kornhuber, J, Members of the WFSBP Task Force Working on this Topic: Peter Riederer, Carla Gallo, Dimitrios Kapogiannis, Andrea Lopez Mato, Florence Thibaut. PubMed PMID:29076399
  12. Needs and quality of life of people with middle-stage dementia and their family carers from the European Actifcare study. When informal care alone may not suffice. Kerpershoek, L, de Vugt, M, Wolfs, C, Woods, B, Jelley, H, Orrell, M, Stephan, A, Bieber, A, Meyer, G, Selbaek, G, Handels, R, Wimo, A, Hopper, L, Irving, K, Marques, M, Gonçalves-Pereira, M, Portolani, E, Zanetti, O, Verhey, F, Actifcare Consortium. PubMed PMID:29068697
  13. Challenges and recommendations for the health-economic evaluation of primary prevention programmes for dementia. Handels, R, Wimo, A. PubMed PMID:29039976
  14. Recommendations for cerebrospinal fluid Alzheimer's disease biomarkers in the diagnostic evaluation of mild cognitive impairment. Herukka, SK, Simonsen, AH, Andreasen, N, Baldeiras, I, Bjerke, M, Blennow, K, Engelborghs, S, Frisoni, GB, Gabryelewicz, T, Galluzzi, S, Handels, R, Kramberger, MG, Kulczyńska, A, Molinuevo, JL, Mroczko, B, Nordberg, A, Oliveira, CR, Otto, M, Rinne, JO, Rot, U, Saka, E, Soininen, H, Struyfs, H, Suardi, S, Visser, PJ, Winblad, B, Zetterberg, H, Waldemar, G. PubMed PMID:28341066
  15. Recommendations for CSF AD biomarkers in the diagnostic evaluation of dementia. Simonsen, AH, Herukka, SK, Andreasen, N, Baldeiras, I, Bjerke, M, Blennow, K, Engelborghs, S, Frisoni, GB, Gabryelewicz, T, Galluzzi, S, Handels, R, Kramberger, MG, Kulczyńska, A, Molinuevo, JL, Mroczko, B, Nordberg, A, Oliveira, CR, Otto, M, Rinne, JO, Rot, U, Saka, E, Soininen, H, Struyfs, H, Suardi, S, Visser, PJ, Winblad, B, Zetterberg, H, Waldemar, G. PubMed PMID:28341065
  16. Predicting progression to dementia in persons with mild cognitive impairment using cerebrospinal fluid markers. Handels, RLH, Vos, SJB, Kramberger, MG, Jelic, V, Blennow, K, van Buchem, M, van der Flier, W, Freund-Levi, Y, Hampel, H, Olde Rikkert, M, Oleksik, A, Pirtosek, Z, Scheltens, P, Soininen, H, Teunissen, C, Tsolaki, M, Wallin, AK, Winblad, B, Verhey, FRJ, Visser, PJ. PubMed PMID:28216393
  17. Caregiver profiles in dementia related to quality of life, depression and perseverance time in the European Actifcare study: the importance of social health. Janssen, EP, de Vugt, M, Köhler, S, Wolfs, C, Kerpershoek, L, Handels, RL, Orrell, M, Woods, B, Jelley, H, Stephan, A, Bieber, A, Meyer, G, Engedal, K, Selbaek, G, Wimo, A, Irving, K, Hopper, L, Gonçalves-Pereira, M, Portolani, E, Zanetti, O, Verhey, FR. PubMed PMID:27869480
  18. Erratum to: Access to timely formal dementia care in Europe: protocol of the Actifcare (ACcess to Timely Formal Care) study. Kerpershoek, L, de Vugt, M, Wolfs, C, Jelley, H, Orrell, M, Woods, B, Stephan, A, Bieber, A, Meyer, G, Engedal, K, Selbaek, G, Handels, R, Wimo, A, Hopper, L, Irving, K, Marques, M, Gonçalves-Pereira, M, Portolani, E, Zanetti, O, Verhey, F, Actifcare Consortium. PubMed PMID:27793151
  19. The Diagnostic and Prognostic Value of Neuropsychological Assessment in Memory Clinic Patients. Jansen, WJ, Handels, RL, Visser, PJ, Aalten, P, Bouwman, F, Claassen, J, van Domburg, P, Hoff, E, Hoogmoed, J, Leentjens, AF, Rikkert, MO, Oleksik, AM, Smid, M, Scheltens, P, Wolfs, C, Verhey, F, Ramakers, IH. PubMed PMID:27716658
  20. Access to timely formal dementia care in Europe: protocol of the Actifcare (ACcess to Timely Formal Care) study. Kerpershoek, L, de Vugt, M, Wolfs, C, Jelley, H, Orrell, M, Woods, B, Stephan, A, Bieber, A, Meyer, G, Engedal, K, Selbaek, G, Handels, R, Wimo, A, Hopper, L, Irving, K, Marques, M, Gonçalves-Pereira, M, Portolani, E, Zanetti, O, Verhey, F, Actifcare Consortium. PubMed PMID:27550084
  21. Combinations of Service Use Types of People With Early Cognitive Disorders. Janssen, N, Handels, RL, Koehler, S, Ramakers, IH, Hamel, RE, Olde Rikkert, MG, Scheltens, P, Bouwman, FH, van der Flier, WM, Wolfs, CA, de Vugt, ME, Evers, SM, Verhey, FR. PubMed PMID:27073042
  22. Added Prognostic Value of Cerebrospinal Fluid Biomarkers in Predicting Decline in Memory Clinic Patients in a Prospective Cohort. Handels, RL, Joore, MA, Vos, SJ, Aalten, P, Ramakers, IH, Rikkert, MO, Scheltens, P, Jansen, WJ, Visser, PJ, van Berckel, BM, van Domburg, P, Smid, M, Hoff, E, Hoogmoed, J, Bouwman, F, Claassen, J, Leentjens, AF, Wolfs, CA, Severens, JL, Verhey, FR. PubMed PMID:27031483
  23. Early cost-utility analysis of general and cerebrospinal fluid-specific Alzheimer's disease biomarkers for hypothetical disease-modifying treatment decision in mild cognitive impairment. Handels, RL, Joore, MA, Tran-Duy, A, Wimo, A, Wolfs, CA, Verhey, FR, Severens, JL. PubMed PMID:26071009
  24. Optimizing the use of expert panel reference diagnoses in diagnostic studies of multidimensional syndromes. Handels, RL, Wolfs, CA, Aalten, P, Bossuyt, PM, Joore, MA, Leentjens, AF, Severens, JL, Verhey, FR. PubMed PMID:25280531
  25. Health economic evaluation of treatments for Alzheimer's disease: impact of new diagnostic criteria. Wimo, A, Ballard, C, Brayne, C, Gauthier, S, Handels, R, Jones, RW, Jonsson, L, Khachaturian, AS, Kramberger, M. PubMed PMID:24605810
  26. Natural progression model of cognition and physical functioning among people with mild cognitive impairment and alzheimer's disease. Handels, RL, Xu, W, Rizzuto, D, Caracciolo, B, Wang, R, Winblad, B, Verhey, FR, Severens, JL, Fratiglioni, L, Joore, MA, Wimo, A. PubMed PMID:23948894
  27. Diagnosing Alzheimer's disease: a systematic review of economic evaluations. Handels, RL, Wolfs, CA, Aalten, P, Joore, MA, Verhey, FR, Severens, JL. PubMed PMID:23727080
  28. Impact of molecular imaging on the diagnostic process in a memory clinic. Ossenkoppele, R, Prins, ND, Pijnenburg, YA, Lemstra, AW, van der Flier, WM, Adriaanse, SF, Windhorst, AD, Handels, RL, Wolfs, CA, Aalten, P, Verhey, FR, Verbeek, MM, van Buchem, MA, Hoekstra, OS, Lammertsma, AA, Scheltens, P, van Berckel, BN. PubMed PMID:23164552
  29. Diagnostic and economic evaluation of new biomarkers for Alzheimer's disease: the research protocol of a prospective cohort study. Handels, RL, Aalten, P, Wolfs, CA, OldeRikkert, M, Scheltens, P, Visser, PJ, Joore, MA, Severens, JL, Verhey, FR. PubMed PMID:22883691
  30. Test sequence of CSF and MRI biomarkers for prediction of AD in subjects with MCI. Vos, S, van Rossum, I, Burns, L, Knol, D, Scheltens, P, Soininen, H, Wahlund, LO, Hampel, H, Tsolaki, M, Minthon, L, Handels, R, L'Italien, G, van der Flier, W, Aalten, P, Teunissen, C, Barkhof, F, Blennow, K, Wolz, R, Rueckert, D, Verhey, F, Visser, PJ. PubMed PMID:22264648
  31. Determinants of care costs of patients with dementia or cognitive impairment. Handels, RL, Wolfs, CA, Aalten, P, Verhey, FR, Severens, JL. PubMed PMID:22214890
  32. Biomarkers as predictors for conversion from mild cognitive impairment to Alzheimer-type dementia: implications for trial design. van Rossum, IA, Vos, S, Handels, R, Visser, PJ. PubMed PMID:20413876
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Dissertation thesis (2014)

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